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	Bentyl
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Bentyl® (Bentyl) is a drug that is used for treating irritable bowel syndrome (IBS). Bentyl is in a class of drugs called anticholinergics. Anticholinergic drugs block the effects of acetylcholine, the chemical transmitter that nerves release in order to cause muscles to contract. They prevent contraction of the muscles by blocking the acetylcholine receptors on the muscle cells. Anticholinergic drugs also have a direct relaxing effect on muscle. Bentyl is used to reduce contraction of the muscles in the intestines. Bentyl was approved by the FDA in 1950.

BENTYL STORAGE: Bentyl Capsules and tablets should be stored at room temperature, between 15° (59°F) and 30°C (86°F).

BENTYL PRESCRIBED FOR: Bentyl is used in the treatment of irritable bowel syndrome.

BENTYL DOSING: The recommended starting oral dose of Bentyl is 20 mg given 4 times daily. The dose can be increased to 40 mg 4 times daily. The recommended intramuscular injection is 20 mg, 4 times daily.

BENTYL DRUG INTERACTIONS: Excessive anticholinergic effects may occur when Bentyl is combined with other drugs with anticholinergic effects such as clemastine (Tavist), diphenhydramine (Benadryl), promethazine (Phenergan), thioridazine (Mellaril), triflupromazine (Stelazine), amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), protriptyline (Vivactil), clozapine (Clozaril), cyclobenzaprine (Flexeril), disopyramide (Norpace). The combined effects of these drugs can lead to a greater incidence of dry mouth, blurred vision, confusion, agitation, increased heart rate, palpitations, constipation, urinary retention (difficulty urinating). Narcotics, e.g., oxycodone (Percocet, Percodan), hydrocodone (Vicodin) can interact with Bentyl and result in greater depression of the muscles of the bowel and bladder resulting in greater constipation and difficulty urinating than may be seen with Bentyl alone.

Bentyl adds to the sedating effects of alcohol and other drugs that cause sleepiness such as the benzodiazepine class of anti-anxiety drugs (e.g., Valium, Ativan, Klonopin, Xanax), the narcotic class of pain medications and its derivatives (e.g., Percocet, Vicodin, Dilaudid, Codeine, Darvon), the tricyclic class of antidepressants (e.g., Elavil, Tofranil, Norpramin), and certain antihypertensive medications (e.g., Catapres, Inderal).

Bentyl can reverse the muscle activity-promoting effects of cisapride (Propulsid) or metoclopramide (Reglan). Conversely, these latter two drugs can reverse the effects of Bentyl.

Antacids and absorbent anti-diarrheals (e.g., Kaopectate) can decrease the absorption of Bentyl. Therefore, doses of antacids or absorbent anti-diarrheals should be separated by at least 2 hours from doses of Bentyl.

BENTYL AND PREGNANCY: There are no adequate studies of the effect of Bentyl in pregnant women at recommended doses (80-160 mg/day). Observation of women who received Bentyl (up to 40 mg/day) containing products during the first trimester of pregnancy did not reveal any increased risk of harm to the fetus.

NURSING MOTHERS: Bentyl is excreted into breast milk. Since there have been reports of apnea (cessation of breathing) when Bentyl has been given to children, it should not be used by nursing mothers.

BENTYL SIDE EFFECTS: Side effects include dry mouth, blurred vision, confusion, agitation, increased heart rate, heart palpitations, constipation, difficulty urinating, and occasionally seizures can occur. Other potential side effects include changes in taste perception, difficulty swallowing, headache, nervousness, drowsiness, weakness, dizziness, impotence, flushing, difficulty falling asleep, nausea, vomiting, rash, bloating and difficulty breathing.