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Like many medicines, Cymbalta works to treat more than one condition. Cymbalta has been approved by the FDA for both the treatment of depression and the management of pain associated with diabetic peripheral neuropathy.

Cymbalta (an SSNRI) targets two chemicals, serotonin and norepinephrine, that are believed to play a role in how the

Description

Cymbalta or common name Duloxetine (du-LOX-uh-teen ) is used to treat mental depression. Cymbalta is also used for pain caused by nerve damage associated with diabetes.

Cymbalta belongs to a group of medicines known as selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). These medicines are thought to work by increasing the activity of chemicals called serotonin and norepinephrine in the brain.

Cymbalta is available only with your doctor's prescription, in the following dosage forms:

• Oral Delayed-release capsules (U.S.)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For Cymbalta, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to Cymbalta. Also tell your doctor and pharmacist if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Cymbalta has not been studied in pregnant women. Cymbalta should only be used during pregnancy if the potential benefit outweighs the potential risk to the baby. Before taking Cymbalta, make sure your doctor knows if you are pregnant (especially if it is the third trimester) or if you may become pregnant.

Breast-feeding—Cymbalta passes into the milk of rats. It is not known whether it passes into human milk. Because the effects of Cymbalta in nursing babies is not known and because of the risks, Cymbalta is not recommended if you are breast-feeding.

Children—Cymbalta must be used with caution in children with depression. Studies have shown occurrences of children thinking about suicide or attempting suicide in clinical trials for this medicine. More study is needed to be sure Cymbalta is safe and effective in children

Older adults—Cymbalta has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults. However, elderly patients are more likely to be sensitive than younger adults to the effects of Cymbalta.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking Cymbalta, it is especially important that your doctor and pharmacist know if you are taking any of the following:

• Antidepressants (fluoxetine [e.g., Prozac], paroxetine [e.g., Paxil])—Taking certain medicines for depression with Cymbalta may increase your chance for side effects.
• Antiarrhythmics (flecainide [e.g., Tambocor], propafenone [e.g., Rythmol], Quinidine [e.g., Quinaglute, Quinidex])—Taking certain medicines for an uneven heartbeat together with Cymbalta may increase the chance of getting serious side effects.
• Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline [e.g., Eldepryl], tranylcypromine [e.g., Parnate])— Do not take Cymbalta while you are taking or within 2 weeks of taking an MAO inhibitor, or you may develop serious side effects. At least 14 days should be allowed between stopping treatment with one medicine (Cymbalta or the MAO inhibitor) and starting treatment with the other
• Phenothiazines (e.g., Compazine, Phenergan, Thorazine)—Taking phenothiazines together with Cymbalta may increase the risk of side effects.
• Tricyclic antidepressants (amitriptyline [e.g., Elavil], desipramine [e.g., Norpramin], imipramine [e.g., Tofranil], nortriptyline [e.g., Aventyl])—Taking certain tricyclic antidepressants together with Cymbalta may increase the risk of side effects.
• Thioridazine (e.g., Mellaril)—Taking thioridazine with Cymbalta may cause serious heart problems.

Other medical problems — The presence of other medical problems may affect the use of Cymbalta. Make sure you tell your doctor if you have any other medical problems, especially:

• Bipolar disorder (mood disorder with alternating episodes of mania and depression) or risk of—May make condition worse. Your doctor will check you for this condition.
• Diabetes mellitus (sugar diabetes)—May increase your blood sugar.
• Kidney disease, severe, or
  Liver disease, severe—Higher blood levels of Cymbalta may occur, increasing the chance of side effects.
• Mania (history of)—The condition may be activated.
• Narrow-angle Glaucoma—May increase your chance of getting blurred vision.
• Seizures (history of)—The risk of seizures may be increased.

Proper Use of Cymbalta

Take Cymbalta only as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Swallow the capsule whole. Do not chew, crush or sprinkle the contents on food or mix with liquids before swallowing.

Cymbalta Dosing

The dose of Cymbalta will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Cymbalta. If your dose is different, do not change it unless your doctor tells you to do so.

The number of capsules that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking Cymbalta

• For oral dosage form (capsule):
• For treatment of depression:
• Adults—40 milligrams (mg) a day (given as 20 mg twice a day) to 60 mg a day (given either once a day or as 30 mg twice a day) with or without meals.
• Children—Use and dose must be determined by your doctor.
• For treatment of pain associated with diabetic peripheral neuropathy
  • Adults—60 milligrams (mg) a day with or without meals.
  • Children—Dose must be determined by your doctor.

Missed Cymbalta dose

If you miss a dose of Cymbalta, take it as soon as possible. However, if it is almost time for your next dose, skip the missed Cymbalta dose and go back to your regular dosing schedule. Do not double Cymbalta doses.

Cymbalta Storage

To store Cymbalta:

• Keep Cymbalta out of the reach of children.
• Store Cymbalta away from heat and direct light.
• Do not store Cymbalta in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated Cymbalta or Cymbalta no longer needed. Ask your health care professional how you should dispose of any Cymbalta you do not use. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using Cymbalta

It is important that your doctor check your progress at regular visits, to allow for changes in your dose and to help reduce any side effects.

Cymbalta has not been shown to add to the effects of alcohol. However, use of alcohol is not recommended in patients who are taking Cymbalta.

Cymbalta may cause some people to be agitated, irritable or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these adverse effects, tell your doctor right away.

Four weeks of Cymbalta may be required before your symptoms improve. It is important to continue Cymbalta after symptoms of depression are relieved.

Do not suddenly stop taking your Cymbalta. If you have been instructed to stop taking Cymbalta, ask you healthcare professional how to slowly decrease the dose. This is to decrease the chance of having discontinuation symptoms such as dizziness, nausea, headache, vomiting, irritability, nightmares, prickling or tingling feelings.

Do not take Cymbalta if you have taken a monoamine oxidase (MAO) inhibitor (furazolidone, phenelzine, procarbazine, selegiline, tranylcypromine) in the past 2 weeks. Do not start taking an MAO inhibitor within 5 days of stopping Cymbalta. If you do, you may develop confusion, agitation, restlessness, stomach or intestinal symptoms, sudden high body temperature, extremely high blood pressure, severe convulsions, or the serotonin syndrome.

For diabetic patients:

• Cymbalta may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests or if you have any questions, check with your doctor.

Cymbalta may cause some people to become drowsy or have blurred vision. Make sure you know how you react to Cymbalta before you drive, use machines, or do anything else that could be dangerous if you are not alert or able to see clearly.

Side Effects of Cymbalta

Along with its needed effects, a medicine may cause some unwanted effects.

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.

• More Common
  • Cough; diarrhea; difficulty having a bowel movement (stool); dizziness ; dry mouth; fever; frequent urination; headache; lack or loss of strength; loss of appetite ; muscle aches; nausea; sleepiness or unusual drowsiness; sleeplessness ; sore throat; stuffy or runny nose; sweating increased; trouble sleeping; unable to sleep; unusual tiredness or weakness; vomiting; weight loss

• Less common
  • Abnormal orgasm; acid or sour stomach ; belching; change or problem with discharge of semen; decreased interest in sexual intercourse; difficulty in moving; erectile dysfunction; fear; feeling of warmth redness of the face, neck, arms and occasionally, upper chest; heartburn; inability to have or keep an erection; indigestion; joint pain; longer than usual time to ejaculation of semen; loose stools; loss in sexual ability, desire, drive, or performance; muscle aching or cramping; muscle pains or stiffness; nervousness; shakiness in legs, arms, hands, feet; stomach discomfort upset or pain; sudden sweating; swollen joints; trembling or shaking of hands or feet; vision blurred

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.