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	Naproxen (Generic Naprosyn)
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Naproxen is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Naproxen works by reducing hormones that cause inflammation and pain in the body. Naproxen is used to reduce pain, inflammation, and stiffness caused by many conditions, such as osteoarthritis, rheumatoid arthritis, gout, ankylosing spondylitis, injury, abdominal cramps associated with menstruation, tendinitis, and bursitis. Naproxen may also be used for purposes other than those listed in this medication guide.

Important Naproxen Note The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your health care professional before using this drug.

Naproxen Uses Naproxen (Naprosyn®, EC Naproxen®, Naprelan®, Anaprox®, Anaprox® DS, Aleve®) is an anti-inflammatory drug. Naproxen relieves pain and inflammation associated with rheumatoid arthritis, osteoarthritis, and juvenile (childhood) arthritis. Naproxen is also effective in treating other mild to moderate pain, including menstrual pain, headache, toothache, and temporarily reduces fever. Naproxen should only be used in children who are over 12 years old.

How to Use Naproxen Take Naproxen tablets by mouth. Follow the directions on the prescription label. Swallow tablets whole with a full glass of water; take tablets in an upright or sitting position. Taking a sip of water first, before taking the tablets, may help you swallow them. If possible take bedtime doses at least 10 minutes before lying down. You can take Naproxen with food to prevent stomach upset. If you are taking the delayed-release tablets swallow them whole; do not crush or chew. Take your doses at regular intervals. Do not take your medicine more often than directed. Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed. Do not give Naproxen to children less than 12 years unless directed by your health care provider.

Naproxen Side Effects Contact your doctor if you experience blood in vomit or bloody, black, or tarry stools. These symptoms could indicate damage to the stomach or intestines, which could be dangerous. If you experience any of the following serious side effects, stop taking Naproxen and seek medical treatment or contact your doctor immediately: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); muscle cramps, numbness, or tingling; ulcers (open sores) in the mouth; rapid weight gain (fluid retention); seizures; decreased hearing or ringing in the ears; yellowing of your skin or eyes (jaundice); or abdominal cramping, heartburn, or indigestion. Other, less serious side effects may be more likely to occur. Continue to take Naproxen and talk to your doctor if you experience dizziness or headache; nausea, diarrhea, or constipation; depression; fatigue or weakness; dry mouth; or irregular menstrual periods. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Naproxen Drug Interactions Before taking Naproxen, tell your doctor if you are taking any of the following drugs: aspirin or another salicylate (form of aspirin) such as salsalate (Disalcid), diflunisal (Dolobid), choline salicylate-magnesium salicylate (Trilisate, Tricosal, others), and magnesium salicylate (Doan's, others); another nonsteroidal anti-inflammatory drug (NSAID) such as diclofenac (Cataflam, Voltaren), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), ibuprofen (Motrin, Advil, others), indomethacin (Indocin), ketoprofen (Orudis, Orudis KT), ketorolac (Toradol), meloxicam (Mobic), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin); an over-the-counter cough, cold, allergy, or pain medicine that contains aspirin, ibuprofen, Naproxen, or ketoprofen; an anticoagulant (blood thinner) such as warfarin (Coumadin); a steroid such as prednisone (Deltasone); insulin or an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase), and others; probenecid (Benemid); lithium (Eskalith, Lithobid, others); or bismuth subsalicylate in drugs such as Pepto-Bismol. You may not be able to take Naproxen, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above. Drugs other than those listed here may also interact with Naproxen. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Naproxen Precautions Avoid prolonged exposure to sunlight. Naproxen may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable. Avoid alcohol or use it with moderation. If you drink more than three alcoholic beverages a day, Naproxen may increase the risk of dangerous stomach bleeding. Talk to your doctor before taking Naproxen if you drink more than 3 alcoholic beverages a day. Use caution when driving, operating machinery, or performing other hazardous activities. Naproxen may cause dizziness. If you experience dizziness, avoid these activities. Many over-the-counter cough, cold, allergy, and pain medicines contain aspirin or other medicines similar to Naproxen (such as ibuprofen, ketoprofen, and others). Before taking any prescription or over-the-counter medicine, talk to your doctor and pharmacist.

Recommended Naproxen Dosage Rheumatoid Arthritis, Osteoarthritis, and Ankylosing Spondylitis: The usual Naproxen dose is two 375- or 500-milligram tablets taken once a day. Your doctor will adjust your Naproxen dose. You should not take more than three 500-milligram tablets daily. Pain, Menstrual Cramps, Acute Tendinitis and Bursitis: The starting Naproxen dose is two 500-milligram tablets taken once a day. For a short time, the doctor may increase the Naproxen dose to three 500-milligram tablets daily. Acute Gout:The usual Naproxen dose is two to three 500-milligram tablets taken together on the first day, then two 500-milligram tablets once daily until the attack subsides. It is not known whether Naproxen is safe for children.

Naproxen Overdose Seek emergency medical attention if a Naproxen overdose is suspected. Symptoms of a Naproxen overdose may include nausea, vomiting, stomach pain, dizziness, drowsiness, headache, ringing in the ears, blurred vision, seizures, sweating, numbness or tingling, little or no urine production, and slow breathing.

Missed Naproxen Dose If you are taking Naproxen on a regular schedule, take the missed dose as soon as you remember. However, if it is almost time for the next Naproxen dose, skip the missed dose and take only the next regularly scheduled Naproxen dose. Do not take a double Naproxen dose. If you are taking Naproxen as needed, take the missed Naproxen dose if it is needed, then wait the recommended or prescribed amount of time before taking another Naproxen dose.

Naproxen Storage Keep Naproxen out of the reach of children in a container that small children cannot open. Store Naproxen at room temperature, between 15 and 30 degrees C (59—86 degrees F); do not freeze. Avoid Naproxen storage above 40 degrees C (104 degrees F). Protect Naproxen from light. Throw away any unused Naproxen after the expiration date.