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PROTOPIC (Tacrolimus) belongs to the class of medications called immunosuppressants. This medication is used on a short-term or intermittent basis to treat the skin condition atopic dermatitis, or eczema. It works on certain areas of the immune system that may be involved in developing this skin condition. It is used when standard treatments have not worked or if there is a reason they cannot be used.

IMPORTANT PROTOPIC NOTE: The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

PROTOPIC USES: Protopic is an ointment containing Tacrolimus, a macrolide immunosuppressant produced by Streptomyces tsukubaensis. Protopic or Tacrolimus ointment is an immunomodulatory drug, which modulates or affects the immune system, and reduces the activity of immune system, benefitting atopic eczema condition that is aggravated by the hyperactivity or hypersensitivity of immune system. Thus Protopic Ointment is used to treat eczema (atopic dermatitis).

HOW TO USE PROTOPIC: Protopic is for adults and children age 2 years and older. Protopic may be used for short or intermittent long periods of treatment, as directed by your doctor. You can use it on all affected areas of your skin, including your face and neck.Use Protopic exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

PROTOPIC SIDE EFFECTS: The most common side effects of Protopic include stinging, soreness, a burning feeling, or itching of the skin treated with Protopic. These side effects are usually mild to moderate, are more common during the first few days of treatment, and typically lessen as your skin heals. Less common side effects include acne, swollen or infected hair follicles, headache, increased sensitivity of the skin to hot or cold temperatures, or flu-like symptoms such as stuffy nose. Some people may get skin tingling, upset stomach, herpes zoster (chicken pox or shingles), or muscle pain. While you are using Protopic, drinking alcohol may cause the skin or face to become flushed or red and feel hot. Call your doctor if side effects continue or become a problem.

PROTOPIC PRECAUTIONS: Follow your doctor's instructions about using Protopic.

HOW IT WORKS: Protopic works by modulating (reducing) immune response.

PROTOPIC STORAGE: Store Protopic at room temperature (59? to 86?F). For instance, never leave Protopic in your car in cold or hot weather. Make sure the cap on the tube is tightly closed. Keep Protopic out of the reach of children.

PROTOPIC NOTES: DO NOT SHARE Protopic with others for whom it was not prescribed. KEEP Protopic out of the reach of children.